Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Englitazone SCHEMBL37697 | 1.00 | PPARG (0.50) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| Englitazone SCHEMBL4727851 | 1.00 | PPARG (0.50) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| Englitazone SCHEMBL20125579 | 1.00 | PPARG (0.50) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| Englitazone SCHEMBL29377687 | 1.00 | PPARG (0.50) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| Englitazone SCHEMBL9367929 | 0.99 | PPARG (0.49) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| Englitazone SCHEMBL22607925 | 0.99 | PPARG (0.49) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| Englitazone SCHEMBL8522765 | 0.99 | PPARG (0.49) | PPARGFFAR1ALDH1A1NPSR1MAPT | |
| SCHEMBL9665642 | 0.92 | FFAR1 (0.59) | PPARGFFAR1ALDH1A1MAPTPPARA | |
| SCHEMBL9664758 | 0.91 | FFAR1 (0.58) | PPARGFFAR1ALDH1A1MAPTPPARA | |
| SCHEMBL6903859 | 0.89 | PPARG (0.52) | PPARGFFAR1ALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200253937-A1 | 5-DEUTERO-THIAZOLIDINE-2,4-DIONE COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | POXEL SA (FR) | 2020-08-13 | — | — | US | disclosed |
| US-20180125827-A1 | 5-DEUTERO-THIAZOLIDINE-2,4-DIONE COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | DEUTERX, LLC | 2018-05-10 | — | — | US | disclosed |
| US-20180125827-A1 | 5-DEUTERO-THIAZOLIDINE-2,4-DIONE COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | DEUTERX, LLC | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125827-A1 | 5-DEUTERO-THIAZOLIDINE-2,4-DIONE COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | DPP4, SLC5A2, GLP1R | PPARG 12/4885FFAR1 1327/4885ALDH1A1 1861/4885 |
| US-20200253937-A1 | 5-DEUTERO-THIAZOLIDINE-2,4-DIONE COMPOUNDS AND METHODS OF TREATING MEDICAL DISORDERS USING SAME | SLC5A2, GLI2, SLC5A1 | PPARG 13/4885FFAR1 1193/4885ALDH1A1 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.