Englitazone

Englitazone

SCHEMBL8522765

O=C1NC(=O)C(Cc2ccc3c(c2)CCC(Cc2ccccc2)O3)S1.[NaH]

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.49
FFAR1 O14842 7/20 0.46
ALDH1A1 P00352 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
MAPT P10636 2/20 0.45
MAOB P27338 2/20 0.43
CA2 P00918 1/20 0.43
PPARA Q07869 2/20 0.42
PTPN1 P18031 1/20 0.42
MAOA P21397 2/20 0.41
CISD1 Q9NZ45 2/20 0.41
KDM4E B2RXH2 1/20 0.40
LMNA P02545 1/20 0.40
HIF1A Q16665 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Englitazone SCHEMBL22607925 1.00 PPARG (0.49) PPARGFFAR1ALDH1A1NPSR1MAPT
Englitazone SCHEMBL4727851 0.99 PPARG (0.50) PPARGFFAR1ALDH1A1NPSR1MAPT
Englitazone SCHEMBL37697 0.99 PPARG (0.50) PPARGFFAR1ALDH1A1NPSR1MAPT
Englitazone SCHEMBL29377687 0.99 PPARG (0.50) PPARGFFAR1ALDH1A1NPSR1MAPT
Englitazone SCHEMBL20125579 0.99 PPARG (0.50) PPARGFFAR1ALDH1A1NPSR1MAPT
Englitazone SCHEMBL20125577 0.99 PPARG (0.50) PPARGFFAR1ALDH1A1NPSR1MAPT
Englitazone SCHEMBL9367929 0.98 PPARG (0.49) PPARGFFAR1ALDH1A1NPSR1MAPT
SCHEMBL9664758 0.92 FFAR1 (0.58) PPARGFFAR1ALDH1A1MAPTPPARA
SCHEMBL9665642 0.91 FFAR1 (0.59) PPARGFFAR1ALDH1A1MAPTPPARA
SCHEMBL6903859 0.88 PPARG (0.52) PPARGFFAR1ALDH1A1NPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999059586-A1 THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-11-25 WO disclosed
EP-0618915-A1 A REDUCTION METHOD FOR SUBSTITUTED 5-METHYLENE-THIAZOLIDINEDIONES THE UPJOHN COMPANY (US) 1994-10-12 EP disclosed
WO-1993013095-A1 A REDUCTION METHOD FOR SUBSTITUTED 5-METHYLENE-THIAZOLIDINEDIONES THE UPJOHN COMPANY (US) 1993-07-08 WO disclosed