Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 13/20 | 0.58 |
| ▸ | PPARA | Q07869 | 4/20 | 0.56 |
| ▸ | PPARG | P37231 | 4/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665642 | 0.99 | FFAR1 (0.59) | FFAR1PPARAPPARGITGB3ITGA2B | |
| Englitazone SCHEMBL22607925 | 0.92 | PPARG (0.49) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL8522765 | 0.92 | PPARG (0.49) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL29377687 | 0.91 | PPARG (0.50) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL20125579 | 0.91 | PPARG (0.50) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL4727851 | 0.91 | PPARG (0.50) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL20125577 | 0.91 | PPARG (0.50) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL37697 | 0.91 | PPARG (0.50) | FFAR1PPARAPPARGALDH1A1MAPT | |
| Englitazone SCHEMBL9367929 | 0.90 | PPARG (0.49) | FFAR1PPARAPPARGALDH1A1MAPT | |
| SCHEMBL10638775 | 0.82 | FFAR1 (0.52) | FFAR1PPARAPPARGMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319189-B1 | THIAZOLIDINEDIONES AS HYPOGLYCEMIC AND ANTI-ATHEROSCLEROSIS AGENTS | PFIZER INC. (US) | 1992-06-10 | — | — | EP | disclosed |
| EP-0319189-A1 | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |
| US-4791125-A | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |