Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18301238 | 0.86 | PTGER1 (0.49) | GRM5NPSR1DHODHMAPTSMN1; SMN2 | |
| SCHEMBL29506339 | 0.85 | GRM5 (0.64) | GRM5NPSR1RXFP1BTKPARP1 | |
| SCHEMBL31249988 | 0.85 | GRM5 (0.64) | GRM5NPSR1RXFP1BTKPARP1 | |
| SCHEMBL31249984 | 0.85 | GRM5 (0.64) | GRM5NPSR1RXFP1BTKPARP1 | |
| SCHEMBL997865 | 0.85 | GRM5 (0.64) | GRM5NPSR1RXFP1BTKPARP1 | |
| Hydrochloric Acid SCHEMBL30105351 | 0.83 | GRM5 (0.62) | GRM5NPSR1RXFP1BTKPARP1 | |
| SCHEMBL29184190 | 0.83 | GRM5 (0.62) | GRM5NPSR1RXFP1BTKPARP1 | |
| Hydrochloric Acid SCHEMBL28843225 | 0.83 | GRM5 (0.62) | GRM5NPSR1RXFP1BTKPARP1 | |
| SCHEMBL28555590 | 0.82 | GRM5 (0.61) | GRM5NPSR1RXFP1BTKPARP1 | |
| SCHEMBL28733309 | 0.82 | KDM1A (0.46) | GRM5NPSR1RXFP1BTKIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10781176-B2 | Catalytic hydrogenation of substituted cyanopyridines and process for preparing substituted pyridylmethylbenzamides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-09-22 | — | — | US | disclosed |
| US-10647674-B2 | — | — | 2020-05-12 | — | — | US | disclosed |
| US-20180297952-A1 | CATALYTIC HYDROGENATION OF SUBSTITUTED CYANOPYRIDINES AND PROCESS FOR PREPARING SUBSTITUTED PYRIDYLMETHYLBENZAMIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-10-18 | — | — | US | disclosed |
| EP-3288922-A1 | CATALYTIC HYDROGENATION OF SUBSTITUTED CYANOPYRIDINES AND PROCESS FOR PREPARING SUBSTITUTED PYRIDYLMETHYLBENZAMIDES | Bayer CropScience Aktiengesellschaft (DE) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016173998-A1 | CATALYTIC HYDROGENATION OF SUBSTITUTED CYANOPYRIDINES AND PROCESS FOR PREPARING SUBSTITUTED PYRIDYLMETHYLBENZAMIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-03 | — | — | WO | disclosed |
| EP-2513188-A1 | HYPERBRANCHED POLYESTER WITH A HYDROPHOBIC NUCLEUS FOR SOLUBILIZING POORLY SOLUBLE ACTIVE SUBSTANCES | BASF SE (DE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073220-A1 | HYPERBRANCHED POLYESTER WITH A HYDROPHOBIC NUCLEUS FOR SOLUBILIZING POORLY SOLUBLE ACTIVE SUBSTANCES | BASF SE (DE) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647674-B2 | — | PYCR1, HCN4, PHYKPL | GRM5 769/4885NPSR1 2179/4885RXFP1 4431/4885 |
| US-20180297952-A1 | CATALYTIC HYDROGENATION OF SUBSTITUTED CYANOPYRIDINES AND PROCESS FOR PREPARING SUBSTITUTED PYRIDYLMETHYLBENZAMIDES | HCN4, PHYKPL, PYCR1 | GRM5 1629/4885NPSR1 2387/4885RXFP1 4539/4885 |
| US-10781176-B2 | Catalytic hydrogenation of substituted cyanopyridines and process for preparing substituted pyridylmethylbenzamides | HCN4, PHYKPL, PYCR1 | GRM5 1629/4885NPSR1 2387/4885RXFP1 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.