Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.80 |
| ▸ | MBOAT4 | Q96T53 | 4/20 | 0.78 |
| ▸ | CCR6 | P51684 | 1/20 | 0.78 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.70 |
| ▸ | USP7 | Q93009 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | STAT3 | P40763 | 1/20 | 0.70 |
| ▸ | RORC | P51449 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20136646 | 0.95 | NOS2 (0.77) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL3994632 | 0.93 | NOS2 (0.80) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL3994634 | 0.93 | NOS2 (0.80) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL20128685 | 0.91 | NOS2 (0.78) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL20128432 | 0.91 | NOS2 (0.77) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL17553178 | 0.89 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL26755157 | 0.89 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL19380279 | 0.88 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL17553174 | 0.88 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL24337036 | 0.88 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135763-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | TRUSTEES OF DARTMOUTH COLLEGE | 2019-05-09 | — | — | US | disclosed |
| US-10189791-B2 | Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180127379-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127379-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | DAD1, OAT, OTC | NOS2 189/4885MBOAT4 2973/4885CCR6 2947/4885 |
| US-10189791-B2 | Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole | DAD1, OAT, OTC | NOS2 189/4885MBOAT4 2973/4885CCR6 2947/4885 |
| US-20190135763-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | DAD1, OAT, OTC | NOS2 189/4885MBOAT4 2973/4885CCR6 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.