Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 9/20 | 0.80 |
| ▸ | MBOAT4 | Q96T53 | 4/20 | 0.78 |
| ▸ | CCR6 | P51684 | 1/20 | 0.78 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.70 |
| ▸ | USP7 | Q93009 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | STAT3 | P40763 | 1/20 | 0.70 |
| ▸ | RORC | P51449 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994634 | 1.00 | NOS2 (0.80) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL20128433 | 0.93 | NOS2 (0.80) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL20128685 | 0.91 | NOS2 (0.78) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL20128432 | 0.91 | NOS2 (0.77) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL20136646 | 0.91 | NOS2 (0.77) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL26755299 | 0.89 | NOS2 (0.83) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL17553178 | 0.89 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL26755157 | 0.89 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL17553174 | 0.88 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 | |
| SCHEMBL19380279 | 0.88 | NOS2 (1.00) | NOS2MBOAT4CCR6KEAP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220031734-A1 | Medical Device Comprising Boswellic Acid | BVW HOLDING AG (CH) | 2022-02-03 | — | — | US | disclosed |
| US-20190135763-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | TRUSTEES OF DARTMOUTH COLLEGE | 2019-05-09 | — | — | US | disclosed |
| US-10189791-B2 | Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180127379-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2018-05-10 | — | — | US | disclosed |
| US-9896475-B2 | Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2018-02-20 | — | — | US | disclosed |
| US-20170267713-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | TRUSTEES OF DARTMOUTH COLLEGE | 2017-09-21 | — | — | US | disclosed |
| US-9539287-B2 | Triterpenoids and compositions containing the same | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2017-01-10 | — | — | US | disclosed |
| US-9205113-B2 | Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2015-12-08 | — | — | US | disclosed |
| US-20150104429-A1 | SYNTHETIC TRITERPENOIDS AND METHODS FOR MODULATING STEM/PROGENITOR CELL GENE EXPRESSION | TRUSTEES OF DARTMOUTH COLLEGE | 2015-04-16 | — | — | US | disclosed |
| US-8981144-B2 | Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2015-03-17 | — | — | US | disclosed |
| US-20130303797-A1 | METHOD FOR SYNTHESIZING 2-CYANO-3,12-DIOXOOLEAN-1, 9(11)-DIEN-28-OIC ACID METHYL ESTER AND DERIVATIVES THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130303607-A1 | Triterpenoids and Compositions Containing the Same | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-11-14 | — | — | US | disclosed |
| EP-1507541-A4 | INHIBITORS AND METHODS OF USE THEREOF | DARTMOUTH COLLEGE (US) | 2009-06-03 | — | — | EP | disclosed |
| US-6974801-B2 | Inhibitors and methods of use thereof | THE TRUSTEES OF DARTMOUNTH COLLEGE (US) | 2005-12-13 | — | — | US | disclosed |
| US-6974801-B2 | Inhibitors and methods of use thereof | THE TRUSTEES OF DARTMOUNTH COLLEGE (US) | 2005-12-13 | — | — | US | disclosed |
| EP-1507541-A2 | INHIBITORS AND METHODS OF USE THEREOF | Trustees of Dartmouth College (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2004064723-A3 | INHIBITORS AND METHODS OF USE THEREOF | DARTMOUTH COLLEGE (US) | 2004-09-23 | — | — | WO | disclosed |
| WO-2004064723-A2 | INHIBITORS AND METHODS OF USE THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2004-08-05 | — | — | WO | disclosed |
| US-20040002463-A1 | Inhibitors and methods of use thereof | THE TRUSTEES OF DARTMOUTH COLLEGE | 2004-01-01 | — | — | US | disclosed |
| US-20040002463-A1 | Inhibitors and methods of use thereof | THE TRUSTEES OF DARTMOUTH COLLEGE | 2004-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303797-A1 | METHOD FOR SYNTHESIZING 2-CYANO-3,12-DIOXOOLEAN-1, 9(11)-DIEN-28-OIC ACID METHYL ESTER AND DERIVATIVES THEREOF | HAAO, CYP8B1, OXER1 | NOS2 592/4885MBOAT4 303/4885CCR6 478/4885 |
| US-20150104429-A1 | SYNTHETIC TRITERPENOIDS AND METHODS FOR MODULATING STEM/PROGENITOR CELL GENE EXPRESSION | BMP2, BMPR2, BMP4 | NOS2 2057/4885MBOAT4 4782/4885CCR6 381/4885 |
| US-20180127379-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | DAD1, OAT, OTC | NOS2 189/4885MBOAT4 2973/4885CCR6 2947/4885 |
| US-20040002463-A1 | Inhibitors and methods of use thereof | IRF3, MIF, IFNG | NOS2 10/4885MBOAT4 937/4885CCR6 2089/4885 |
| US-20170267713-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | OXER1, CYP24A1, PYGL | NOS2 618/4885MBOAT4 3820/4885CCR6 2472/4885 |
| US-20130303607-A1 | Triterpenoids and Compositions Containing the Same | PGGT1B, BET1, BSG | NOS2 1556/4885MBOAT4 1374/4885CCR6 1758/4885 |
| US-10189791-B2 | Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole | DAD1, OAT, OTC | NOS2 189/4885MBOAT4 2973/4885CCR6 2947/4885 |
| US-20190135763-A1 | PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE | DAD1, OAT, OTC | NOS2 189/4885MBOAT4 2973/4885CCR6 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.