Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015295 | 1.00 | LMNA (0.51) | LMNAKCNH2HRH1ATML3MBTL1 | |
| SCHEMBL20128497 | 0.90 | SPHK2 (0.44) | LMNAL3MBTL1SPHK2SPHK1 | |
| SCHEMBL20128495 | 0.86 | HRH1 (0.44) | LMNAHRH1GBA1SPHK2SPHK1 | |
| SCHEMBL20128478 | 0.83 | CYP2D6 (0.45) | GBA1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL6304543 | 0.83 | GBA1 (0.46) | GBA1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL8336619 | 0.83 | LMNA (0.56) | LMNAHRH1ATML3MBTL1 | |
| SCHEMBL8339280 | 0.83 | LMNA (0.56) | LMNAHRH1ATML3MBTL1 | |
| SCHEMBL1303955 | 0.83 | GBA1 (0.46) | GBA1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL1303954 | 0.83 | GBA1 (0.46) | GBA1SPHK2SPHK1ALDH1A1 | |
| SCHEMBL8336623 | 0.83 | LMNA (0.56) | LMNAHRH1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040760-B2 | Pyrrolidine compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-08-07 | — | — | US | disclosed |
| US-20180127364-A1 | PYRROLIDINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127364-A1 | PYRROLIDINE COMPOUND | CAT, POLI, PPOX | LMNA 4051/4885KCNH2 1432/4885HRH1 1127/4885 |
| US-10040760-B2 | Pyrrolidine compound | CAT, POLI, PPOX | LMNA 4051/4885KCNH2 1432/4885HRH1 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.