Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16423449 | 0.88 | ALDH1A1 (0.60) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL16423450 | 0.88 | ALDH1A1 (0.60) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL22278705 | 0.87 | LMNA (0.55) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL30116269 | 0.87 | KDM4E (0.52) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL20271129 | 0.87 | KDM4E (0.52) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL14249111 | 0.86 | LMNA (0.48) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL28518931 | 0.85 | ALDH1A1 (0.51) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL17038122 | 0.85 | MAPT (0.56) | KDM4EMAPK1HCAR3LMNAKMT2A | |
| SCHEMBL16424383 | 0.84 | PKM (0.69) | KDM4EPKMMAPK1RAB9AHCAR3 | |
| SCHEMBL906299 | 0.83 | RECQL (0.54) | KDM4EPKMMAPK1RAB9AHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | EP300, HDAC3, HDAC1 | KDM4E 478/4885PKM 1910/4885MAPK1 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.