Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | GLA | P06280 | 2/20 | 0.76 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CDC14B | O60729 | 1/20 | 0.45 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30476189 | 1.00 | ALDH1A1 (0.76) | ALDH1A1GLAMAOAKDM4EMAPT | |
| Methanesulfonamide SCHEMBL4789997 | 0.91 | ALDH1A1 (0.64) | ALDH1A1GLAMAOAKDM4EMAPT | |
| Methanesulfonamide SCHEMBL4790635 | 0.89 | ALDH1A1 (0.62) | ALDH1A1GLAMAOAKDM4EMAPT | |
| SCHEMBL4234802 | 0.88 | ALDH1A1 (0.69) | ALDH1A1GLAMAOAKDM4EMAPT | |
| SCHEMBL516363 | 0.83 | ALDH1A1 (0.54) | ALDH1A1GLAMAOAKDM4EMAPT | |
| SCHEMBL29685650 | 0.83 | ALDH1A1 (0.54) | ALDH1A1GLAMAOAKDM4EMAPT | |
| SCHEMBL4586087 | 0.81 | ALDH1A1 (0.53) | ALDH1A1GLAMAOAKDM4EMAPT | |
| SCHEMBL11401526 | 0.81 | ALDH1A1 (0.53) | ALDH1A1GLAMAOAKDM4EMAPT | |
| SCHEMBL6238717 | 0.81 | ALDH1A1 (0.53) | ALDH1A1GLAMAOAKDM4EMAPT | |
| Silver SCHEMBL11471729 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GLAMAOAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891354-B1 | N-AMINOALKYLDIBENZOFURANCARBOXAMIDES AS DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORP (US) | 2001-09-12 | — | — | EP | claimed |
| EP-3285735-B1 | DELIVERY OF SURFACTANT SOLUBLE ANTI-DANDRUFF AGENT | PROCTER & GAMBLE (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3061759-B1 | NITRILE SUBSTITUTED DIBENZOFURANS | IDEMITSU KOSAN CO (JP) | 2019-12-25 | — | — | EP | disclosed |
| EP-3072943-B1 | DIBENZOFURAN/CARBAZOLE-SUBSTITUTED BENZONITRILES | IDEMITSU KOSAN CO (JP) | 2018-05-02 | — | — | EP | disclosed |
| CN-105902533-B | Purposes of the compound cercosporamide in immunopotentiator is prepared | 浙江省医学科学院 | 2018-04-20 | — | — | CN | disclosed |
| CN-105902533-B | Purposes of the compound cercosporamide in immunopotentiator is prepared | 浙江省医学科学院 | 2018-04-20 | — | — | CN | disclosed |
| EP-3072943-A1 | DIBENZOFURAN/CARBAZOLE-SUBSTITUTED BENZONITRILES | Idemitsu Kosan Co., Ltd. (JP) | 2016-09-28 | — | — | EP | disclosed |
| EP-3061759-A1 | NITRILE SUBSTITUTED DIBENZOFURANS | Idemitsu Kosan Co., Ltd (JP) | 2016-08-31 | — | — | EP | disclosed |
| CN-105902533-A | Application of compound cercosporamide in preparation of immunoenhancer | 浙江省医学科学院 | 2016-08-31 | — | — | CN | disclosed |
| US-20160248026-A1 | NITRILE SUBSTITUTED DIBENZOFURANS | IDEMITSU KOSAN CO., LTD. (JP) | 2016-08-25 | — | — | US | disclosed |
| US-4935511-A | Nervous system, gastrointestinal disorders | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| WO-1990006113-A1 | SUBSTITUTED SATURATED AND UNSATURATED INDOLE QUINOLINE AND BENZAZEPINE CARBOXAMIDES AND THEIR USE AS PHARMACOLOGICAL AGENTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| WO-1990006309-A1 | HETEROAZABENZOBICYCLIC CARBOXAMIDE 5-HT3, ANTAGONISTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| US-4933445-A | Heteroazabenzobicyclic carboxamide 5-HT3 antagonists | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-12 | — | — | US | disclosed |
| US-4920219-A | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4920227-A | Benzobicyclic carboxamide 5-HT3 antagonists | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989010364-A1 | DIBENZOFURANCARBOXAMIDES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-11-02 | — | — | WO | disclosed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4863921-A | Dibenzofurancarboxamides and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160248026-A1 | NITRILE SUBSTITUTED DIBENZOFURANS | DBF4, NXF1, NCF1 | ALDH1A1 1679/4885GLA 3390/4885MAOA 2114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.