Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179284 | 0.80 | CYP19A1 (0.42) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL31256061 | 0.80 | CYP19A1 (0.42) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL9474833 | 0.76 | CYP19A1 (0.48) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL20774860 | 0.76 | CYP19A1 (0.40) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL4630149 | 0.76 | CYP19A1 (0.40) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL9589700 | 0.76 | CYP19A1 (0.40) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL85681 | 0.76 | CYP19A1 (0.40) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL8289716 | 0.76 | CYP19A1 (0.40) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL19573760 | 0.76 | HSP90AA1 (0.42) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 | |
| SCHEMBL28453438 | 0.76 | CYP19A1 (0.44) | CYP19A1KDM4EHSP90AA1NAPRTHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179594-A1 | GLP-1R AGONISTS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2021-06-17 | — | — | US | disclosed |
| US-10420752-B2 | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis | CASE WESTERN RESERVE UNIVERSITY (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180125829-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10420752-B2 | Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis | HPGDS, HPGD, PHGDH | CYP19A1 1306/4885KDM4E 1600/4885HSP90AA1 926/4885 |
| US-20180125829-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS | HPGDS, HPGD, PHGDH | CYP19A1 1306/4885KDM4E 1600/4885HSP90AA1 926/4885 |
| US-20210179594-A1 | GLP-1R AGONISTS AND USES THEREOF | GLP1R, GPR119, GIPR | CYP19A1 1020/4885KDM4E 3200/4885HSP90AA1 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.