Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014788 | 0.89 | TAAR1 (0.43) | TAAR1SYKCDC7ROCK2MAP4K4 | |
| SCHEMBL2017434 | 0.87 | TAAR1 (0.40) | TAAR1SYKCDC7ROCK2MAP4K4 | |
| SCHEMBL2015779 | 0.86 | PIK3CD (0.44) | TAAR1SYKCCR1CCR8CDC7 | |
| SCHEMBL2013332 | 0.83 | MAP4K4 (0.42) | TAAR1SYKCDC7ROCK2MAP4K4 | |
| SCHEMBL2012708 | 0.82 | CCR1 (0.39) | SYKCCR1CCR8CDC7ROCK2 | |
| SCHEMBL2011259 | 0.79 | TAAR1 (0.43) | TAAR1SYKCCR1CCR8CDC7 | |
| SCHEMBL2014148 | 0.78 | PIK3CD (0.47) | SYKCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL2013014 | 0.77 | PIK3CD (0.45) | SYKCCR1CCR8CDC7ROCK2 | |
| SCHEMBL2012706 | 0.75 | TOP2A (0.42) | CCR1CCR8CDC7ROCK2MAP4K4 | |
| SCHEMBL2016433 | 0.73 | TAAR1 (0.43) | TAAR1SYKKDM4EPIK3CDHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |