Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014788 | 0.89 | TAAR1 (0.43) | PIK3CDTAAR1SYKL3MBTL1KDM4E | |
| SCHEMBL2013016 | 0.86 | TAAR1 (0.41) | PIK3CDTAAR1SYKCCR1CCR8 | |
| SCHEMBL12491178 | 0.85 | BCL2 (0.47) | PIK3CDTAAR1SYKKDM4ECYP3A4 | |
| SCHEMBL2017434 | 0.85 | TAAR1 (0.40) | PIK3CDTAAR1SYKKDM4ECDC7 | |
| SCHEMBL2013332 | 0.83 | MAP4K4 (0.42) | PIK3CDTAAR1SYKKDM4ECDC7 | |
| SCHEMBL2015005 | 0.82 | PIK3CD (0.44) | PIK3CDL3MBTL1CCR1CCR8MMP14 | |
| SCHEMBL2012666 | 0.82 | TAAR1 (0.47) | TAAR1KMT2AHTR1A | |
| SCHEMBL2015741 | 0.81 | L3MBTL1 (0.44) | L3MBTL1CCR1CCR8MMP14KDM4E | |
| SCHEMBL2011259 | 0.79 | TAAR1 (0.43) | PIK3CDTAAR1SYKCCR1CCR8 | |
| SCHEMBL2015154 | 0.79 | TAAR1 (0.41) | TAAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |