Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014788 | 0.88 | TAAR1 (0.43) | TAAR1SYKKDM4ECDC7ROCK2 | |
| SCHEMBL2013016 | 0.87 | TAAR1 (0.41) | TAAR1SYKKDM4ECDC7ROCK2 | |
| SCHEMBL2015779 | 0.85 | PIK3CD (0.44) | TAAR1SYKKDM4ECDC7ROCK2 | |
| SCHEMBL2015837 | 0.84 | KDM4E (0.38) | SYKKDM4ECDC7ROCK2MAP4K4 | |
| SCHEMBL2013332 | 0.82 | MAP4K4 (0.42) | TAAR1SYKKDM4ECDC7ROCK2 | |
| SCHEMBL2017433 | 0.81 | PIK3CD (0.43) | SYKKDM4ECDC7ROCK2MAP4K4 | |
| SCHEMBL2015835 | 0.79 | KDM4E (0.43) | KDM4ECDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL2011259 | 0.78 | TAAR1 (0.43) | TAAR1SYKKDM4ECDC7ROCK2 | |
| SCHEMBL2015218 | 0.74 | CDC7 (0.40) | SYKKDM4ECDC7ROCK2MAP4K4 | |
| SCHEMBL2016433 | 0.72 | TAAR1 (0.43) | TAAR1SYKKDM4EPIK3CDGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |