Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286958 | 0.92 | ADRA1A (0.53) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| SCHEMBL10365161 | 0.91 | CACNA1B (0.61) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| SCHEMBL10365237 | 0.89 | CACNA1C (0.62) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL247471 | 0.88 | MAPT (0.70) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL49368 | 0.88 | MAPT (0.70) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL29801590 | 0.88 | MAPT (0.70) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL137617 | 0.88 | ADRA1A (0.71) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL137616 | 0.88 | ADRA1A (0.71) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL1491200 | 0.88 | ADRA1A (0.71) | ADRA1AADORA3ADRA2AADRA2BADRA2C | |
| Manidipine 6300 SCHEMBL6275097 | 0.88 | ADRA1A (0.71) | ADRA1AADORA3ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11123335-B2 | Method for preventing lung diseases in smokers and non-smokers using antihypertensive drug | SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) | 2021-09-21 | — | — | US | disclosed |
| US-20180125833-A1 | METHOD FOR PREVENTING LUNG DISEASES IN SMOKERS AND NON-SMOKERS USING ANTIHYPERTENSIVE DRUG | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125833-A1 | METHOD FOR PREVENTING LUNG DISEASES IN SMOKERS AND NON-SMOKERS USING ANTIHYPERTENSIVE DRUG | TGFB1, TGFB2, AGTR1 | ADRA1A 42/4885ADORA3 1357/4885ADRA2A 101/4885 |
| US-11123335-B2 | Method for preventing lung diseases in smokers and non-smokers using antihypertensive drug | TGFB1, TGFB2, AGTR1 | ADRA1A 42/4885ADORA3 1357/4885ADRA2A 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.