Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estradiol Cypionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol Cypionate SCHEMBL29404977 | 1.00 | LMNA (1.00) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL41551 | 1.00 | LMNA (1.00) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL19236258 | 1.00 | LMNA (1.00) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL12754433 | 1.00 | LMNA (1.00) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL28333106 | 1.00 | LMNA (1.00) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL6195927 | 0.96 | LMNA (0.92) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL3199191 | 0.93 | LMNA (0.87) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| Estradiol Cypionate SCHEMBL15532173 | 0.92 | LMNA (0.85) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| SCHEMBL4649449 | 0.90 | MAPT (0.82) | LMNAMAPTCYP3A4KMT2AMEN1 | |
| SCHEMBL32662059 | 0.90 | LMNA (0.82) | LMNAMAPTCYP3A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158575-A1 | COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES | Natural Extraction Systems, LLC (US) | 2021-08-12 | — | — | WO | disclosed |
| US-20180125859-A1 | Methods for Inhibiting the Development of Huntington's Disease | CARNAZZA JAMES A (US) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125859-A1 | Methods for Inhibiting the Development of Huntington's Disease | HTT, HYPK, HSD17B11 | ESR1 103/4885LMNA 2422/4885MAPT 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.