Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20132409 | 0.82 | MAPK1 (0.48) | HDAC3HDAC6HDAC1HDAC2KDM4E | |
| SCHEMBL26699160 | 0.81 | HDAC3 (0.41) | HDAC3HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL1366363 | 0.74 | HDAC6 (1.00) | HDAC3HDAC6HDAC1HDAC2 | |
| SCHEMBL20160948 | 0.73 | HDAC3 (0.42) | HDAC3HDAC6HDAC1HDAC2KMT2A | |
| SCHEMBL20128319 | 0.69 | HDAC1 (0.67) | HDAC3HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL20132421 | 0.69 | HDAC1 (0.61) | HDAC3HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL20132370 | 0.67 | HDAC3 (0.65) | HDAC3HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL26697537 | 0.67 | HDAC3 (0.65) | HDAC3HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL20132366 | 0.67 | HDAC6 (0.59) | HDAC3HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL20132369 | 0.67 | HDAC3 (0.65) | HDAC3HDAC6HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538084-B1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | ACETYLON PHARMACEUTICALS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| US-10927072-B2 | Phenyl and pyridinyl hydroxamic acids | ACETYLON PHARMACEUTICALS, INC. (US) | 2021-02-23 | — | — | US | disclosed |
| US-10370324-B2 | Phenyl and pyridinyl hydroxamic acids | ACETYLON PHARMACEUTICALS, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180127356-A1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | ACETYLON PHARMACEUTICALS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370324-B2 | Phenyl and pyridinyl hydroxamic acids | HDAC6, HDAC1, HDAC5 | HDAC3 4/4885HDAC6 1/4885HDAC1 2/4885 |
| US-10927072-B2 | Phenyl and pyridinyl hydroxamic acids | HDAC6, HDAC1, HDAC5 | HDAC3 4/4885HDAC6 1/4885HDAC1 2/4885 |
| US-20180127356-A1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | HDAC6, HDAC1, HDAC5 | HDAC3 4/4885HDAC6 1/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.