Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.35 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907276 | 0.90 | DRD2 (0.41) | CYP2D6DRD2CYP19A1DRD3IDH1 | |
| SCHEMBL8376129 | 0.82 | DRD2 (0.41) | CYP2D6DRD2DRD3IDH1GRIN1 | |
| SCHEMBL2669660 | 0.82 | DRD2 (0.41) | CYP2D6DRD2DRD3IDH1GRIN1 | |
| SCHEMBL1615480 | 0.81 | DRD2 (0.51) | CYP2D6DRD2CYP19A1DRD3IDH1 | |
| SCHEMBL25159078 | 0.78 | CYP19A1 (0.35) | CYP19A1 | |
| SCHEMBL2463278 | 0.76 | CYP2D6 (0.44) | CYP2D6DRD2CYP19A1DRD3IDH1 | |
| SCHEMBL20000788 | 0.75 | CYP2D6 (0.42) | CYP2D6DRD2CYP19A1DRD3IDH1 | |
| SCHEMBL30666578 | 0.71 | DRD2 (0.44) | CYP2D6DRD2CYP19A1DRD3IDH1 | |
| SCHEMBL14452400 | 0.71 | DRD2 (0.41) | CYP2D6DRD2DRD3IDH1GRIN1 | |
| SCHEMBL12891737 | 0.71 | DRD2 (0.44) | CYP2D6DRD2CYP19A1DRD3IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230123591-A1 | TGF-ß INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-04-20 | — | — | US | disclosed |
| US-20180127426-A1 | TGF-Beta Inhibitors | MIDCAP FINANCIAL TRUST | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127426-A1 | TGF-Beta Inhibitors | TGFBR1, TGFBR2, TGFB1 | CYP2D6 3892/4885DRD2 4531/4885CYP19A1 1851/4885 |
| US-20230123591-A1 | TGF-ß INHIBITORS | TGFBR1, TGFBR2, TGFB1 | CYP2D6 3120/4885DRD2 4551/4885CYP19A1 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.