Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.68 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.62 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.62 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24713318 | 0.87 | ALDH1A1 (0.68) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 | |
| SCHEMBL1548224 | 0.82 | CYP17A1 (1.00) | ALDH1A1CYP17A1CYP19A1HSD11B1SPHK2 | |
| SCHEMBL29375651 | 0.81 | ALDH1A1 (0.59) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 | |
| SCHEMBL3318511 | 0.81 | HPGD (0.75) | ALDH1A1CYP17A1CYP19A1HSD11B1SPHK2 | |
| SCHEMBL1046240 | 0.77 | HSD11B1 (1.00) | HSD11B1HSD11B2 | |
| Abc-294640 SCHEMBL21116115 | 0.76 | SPHK2 (1.00) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 | |
| Abc-294640 SCHEMBL31060730 | 0.76 | SPHK2 (1.00) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 | |
| Abc-294640 SCHEMBL20592375 | 0.76 | SPHK2 (1.00) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 | |
| Abc-294640 SCHEMBL1548333 | 0.76 | SPHK2 (1.00) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 | |
| SCHEMBL24064926 | 0.76 | SPHK2 (0.80) | ALDH1A1CYP17A1CYP19A1HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180125831-A1 | COMBINATION THERAPIES FOR TREATING CANCER | REDHILL BIOPHARMA LTD (IL) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125831-A1 | COMBINATION THERAPIES FOR TREATING CANCER | TPMT, KRAS, ACE | ALDH1A1 66/4885CYP17A1 1490/4885CYP19A1 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.