Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12631069 | 0.87 | MEN1 (0.53) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL23589263 | 0.85 | PTGDR2 (0.54) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5447871 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2014620 | 0.81 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10197528 | 0.81 | NPC1 (0.49) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10197531 | 0.78 | NPC1 (0.46) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1583614 | 0.78 | POLB (0.48) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL29751809 | 0.78 | POLB (0.48) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6221568 | 0.77 | PTGDR2 (0.57) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1990199 | 0.77 | MAPK1 (0.46) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073273-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |