Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MPO | P05164 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1461064 | 1.00 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL18029216 | 1.00 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL1461062 | 1.00 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL29809866 | 1.00 | KMT2A (0.61) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL2013301 | 0.89 | MTNR1A (0.58) | KMT2AKDM4EMAPTLMNATSHR | |
| Hydrochloric Acid SCHEMBL28174730 | 0.88 | MTNR1A (0.57) | KMT2AKDM4EMAPTLMNATSHR | |
| Hydrochloric Acid SCHEMBL28174732 | 0.88 | MTNR1A (0.57) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL24328917 | 0.86 | SMN1; SMN2 (0.60) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL28409765 | 0.86 | SMN1; SMN2 (0.60) | KMT2AKDM4EMAPTLMNATSHR | |
| SCHEMBL24328893 | 0.86 | MTNR1A (0.57) | KMT2AKDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513016-B1 | IMPROVED METHOD FOR PRODUCING INTERMEDIATES FOR THE PRODUCTION OF MACROCYCLES THAT ARE INHIBITORS OF THE PROTEASOMIC DEGRADATION OF P27, SUCH AS ARGYRIN AND DERIVATIVES THEREOF | Helmholtz Zentrum für Infektionsforschung GmbH (DE) | 2016-02-17 | — | — | EP | claimed |
| US-20120295941-A1 | Method For Producing Intermediates For The Production Of Macrocycles That Are Inhibitors Of The Proteasomic Degradation of P27, Such As Argyrin And Derivatives Thereof | GOTTFRIED WILHELM LEIBNIZ UNIVERSITAT (DE) | 2012-11-22 | — | — | US | claimed |
| EP-2513016-A1 | IMPROVED METHOD FOR PRODUCING INTERMEDIATES FOR THE PRODUCTION OF MACROCYCLES THAT ARE INHIBITORS OF THE PROTEASOMIC DEGRADATION OF P27, SUCH AS ARGYRIN AND DERIVATIVES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2012-10-24 | — | — | EP | claimed |
| WO-2011073173-A1 | IMPROVED METHOD FOR PRODUCING INTERMEDIATES FOR THE PRODUCTION OF MACROCYCLES THAT ARE INHIBITORS OF THE PROTEASOMIC DEGRADATION OF P27, SUCH AS ARGYRIN AND DERIVATIVES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2011-06-23 | — | — | WO | claimed |
| EP-2513016-B1 | IMPROVED METHOD FOR PRODUCING INTERMEDIATES FOR THE PRODUCTION OF MACROCYCLES THAT ARE INHIBITORS OF THE PROTEASOMIC DEGRADATION OF P27, SUCH AS ARGYRIN AND DERIVATIVES THEREOF | Helmholtz Zentrum für Infektionsforschung GmbH (DE) | 2016-02-17 | — | — | EP | disclosed |
| US-8853249-B2 | Method for producing intermediates for the production of macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof | Helmholtz-Zentrum für Infektionsforschungs GmbH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20120295941-A1 | Method For Producing Intermediates For The Production Of Macrocycles That Are Inhibitors Of The Proteasomic Degradation of P27, Such As Argyrin And Derivatives Thereof | GOTTFRIED WILHELM LEIBNIZ UNIVERSITAT (DE) | 2012-11-22 | — | — | US | disclosed |
| EP-2513016-A1 | IMPROVED METHOD FOR PRODUCING INTERMEDIATES FOR THE PRODUCTION OF MACROCYCLES THAT ARE INHIBITORS OF THE PROTEASOMIC DEGRADATION OF P27, SUCH AS ARGYRIN AND DERIVATIVES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073173-A1 | IMPROVED METHOD FOR PRODUCING INTERMEDIATES FOR THE PRODUCTION OF MACROCYCLES THAT ARE INHIBITORS OF THE PROTEASOMIC DEGRADATION OF P27, SUCH AS ARGYRIN AND DERIVATIVES THEREOF | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295941-A1 | Method For Producing Intermediates For The Production Of Macrocycles That Are Inhibitors Of The Proteasomic Degradation of P27, Such As Argyrin And Derivatives Thereof | SKP2, CDKN1A, MDM2 | KMT2A 1847/4885KDM4E 1914/4885MAPT 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.