Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133198 | 0.81 | CYP2A6 (0.46) | CYP11B2CYP11B1CYP19A1CYP17A1CYP2A6 | |
| SCHEMBL20133194 | 0.81 | METAP2 (0.45) | CYP11B2CYP11B1CYP19A1CYP17A1CYP2A6 | |
| SCHEMBL20133255 | 0.80 | CYP2A6 (0.44) | CYP11B2CYP11B1CYP19A1CYP17A1CYP2A6 | |
| SCHEMBL20133195 | 0.75 | CYP2A6 (0.42) | L3MBTL1KDM4ENPC1RAB9ACYP11B2 | |
| SCHEMBL26788955 | 0.73 | KDM4E (0.43) | L3MBTL1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL20033223 | 0.73 | CYP11B2 (0.46) | L3MBTL1KDM4ENPC1RAB9ACYP11B2 | |
| SCHEMBL11965548 | 0.72 | PIK3CA (0.40) | L3MBTL1KDM4ENPC1RAB9ACYP11B2 | |
| SCHEMBL13471319 | 0.71 | GRM5 (0.40) | L3MBTL1KDM4ENPC1RAB9ACYP11B2 | |
| SCHEMBL21168109 | 0.71 | HSP90AA1 (0.44) | L3MBTL1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL19412590 | 0.70 | L3MBTL1 (0.41) | L3MBTL1KDM4ENPC1RAB9ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155690-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2020-05-21 | — | — | US | disclosed |
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125821-A1 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | CRBN, VHL, UBQLN2 | L3MBTL1 1300/4885KDM4E 1212/4885NPC1 3216/4885 |
| US-20200155690-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | L3MBTL1 1152/4885KDM4E 1613/4885NPC1 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.