Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | CCR8 | P51685 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015807 | 0.88 | MAPK14 (0.36) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2011836 | 0.87 | LMNA (0.40) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2011259 | 0.85 | TAAR1 (0.43) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2015662 | 0.81 | CYP11B1 (0.38) | CYP3A4NQO2ADORA2BTLR7PDE10A | |
| SCHEMBL2050742 | 0.77 | PIK3CD (0.42) | KDM4ELMNACYP3A4CYP2D6MAPT | |
| SCHEMBL2013339 | 0.76 | PIK3CD (0.43) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2016907 | 0.76 | KDM4E (0.44) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2011511 | 0.74 | KDM4E (0.40) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2015805 | 0.73 | PIK3CD (0.43) | KDM4ECCR1CCR5CCR8LMNA | |
| SCHEMBL2012265 | 0.72 | PIK3CD (0.42) | KDM4ECCR1CCR5CCR8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |