Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 6/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013837 | 0.97 | BTK (0.37) | CCR4IDEBTKMAPTMAPK1 | |
| SCHEMBL2012342 | 0.87 | MAPT (0.42) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL2017050 | 0.87 | SLC40A1 (0.40) | MAPTMAPK1HTTKMT2ANPSR1 | |
| SCHEMBL2012273 | 0.87 | HTT (0.39) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL2015850 | 0.86 | L3MBTL1 (0.37) | CCR4MAPTMAPK1HTTMEN1 | |
| SCHEMBL2016487 | 0.85 | GBA1 (0.35) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL2015620 | 0.85 | SMO (0.40) | BTKMAPTMAPK1HTTMEN1 | |
| SCHEMBL2014635 | 0.85 | LMNA (0.40) | MAPTHTTKMT2ANPSR1RAB9A | |
| SCHEMBL2017028 | 0.84 | LMNA (0.43) | MAPTHTTKMT2ANPSR1NPC1 | |
| SCHEMBL2017422 | 0.83 | MAPT (0.43) | MAPTHTTKMT2ANPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |