Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CASP9 | P55211 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014980 | 0.93 | SLC40A1 (0.38) | SLC40A1METAP2MAPTHTTSMN1; SMN2 | |
| SCHEMBL2014977 | 0.93 | SLC40A1 (0.38) | SLC40A1METAP2MAPTHTTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2016494 | 0.90 | ATR (0.33) | SLC40A1MMP2MMP9MAPTHTT | |
| SCHEMBL2017050 | 0.90 | SLC40A1 (0.40) | SLC40A1METAP2MAPTHTTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2012687 | 0.90 | MAPT (0.33) | SLC40A1MMP2MMP9MAPTHTT | |
| Trifluoroacetic Acid SCHEMBL2013265 | 0.89 | KHK (0.33) | METAP2CRHR1 | |
| Trifluoroacetic Acid SCHEMBL2013474 | 0.89 | GPR6 (0.32) | SLC40A1MMP2MMP9METAP2MAPT | |
| SCHEMBL2013539 | 0.86 | LMNA (0.33) | SLC40A1MAPTHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2013535 | 0.86 | LMNA (0.33) | SLC40A1MAPTHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL2016578 | 0.84 | CNR2 (0.38) | L3MBTL1RAB9AAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |