Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013535 | 1.00 | LMNA (0.33) | LMNAMAPK1HTTSMN1; SMN2CDC7 | |
| SCHEMBL2014977 | 0.90 | SLC40A1 (0.38) | LMNAMAPK1HTTSMN1; SMN2CDC7 | |
| SCHEMBL2014980 | 0.90 | SLC40A1 (0.38) | LMNAMAPK1HTTSMN1; SMN2CDC7 | |
| SCHEMBL2013942 | 0.90 | HTT (0.45) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL2017050 | 0.86 | SLC40A1 (0.40) | LMNAMAPK1HTTSMN1; SMN2CDC7 | |
| Trifluoroacetic Acid SCHEMBL2013515 | 0.86 | SLC40A1 (0.36) | LMNAHTTSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL2051072 | 0.85 | HTR1A (0.35) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL2013531 | 0.81 | PIK3CD (0.38) | L3MBTL1LRRK2BRAF | |
| SCHEMBL2014290 | 0.81 | KDM4E (0.36) | LMNAMAPTL3MBTL1KCNMA1SLC40A1 | |
| SCHEMBL2014289 | 0.81 | KDM4E (0.36) | LMNAMAPTL3MBTL1KCNMA1SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |