Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900636 | 0.84 | NEK2 (0.34) | USP2GAAMAPTALOX15GFER | |
| SCHEMBL30154873 | 0.84 | NEK2 (0.34) | USP2GAAMAPTALOX15GFER | |
| SCHEMBL30536162 | 0.79 | JAK2 (0.39) | JAK2JAK1TYK2JAK3MAP4K4 | |
| SCHEMBL28563124 | 0.75 | TDO2 (0.37) | JAK2JAK1TYK2JAK3BACE1 | |
| SCHEMBL30536195 | 0.75 | NOS3 (0.39) | JAK2JAK1TYK2JAK3MAP4K4 | |
| SCHEMBL28076460 | 0.72 | HRH4 (0.41) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL16053346 | 0.72 | OPRL1 (0.40) | PDE10A | |
| SCHEMBL21300026 | 0.72 | ALOX5AP (0.37) | JAK2JAK1TYK2JAK3MAP4K4 | |
| SCHEMBL22089675 | 0.70 | JAK2 (0.36) | JAK2JAK1TYK2JAK3PARP1 | |
| SCHEMBL482014 | 0.69 | MAPK1 (0.43) | MAP4K4PARP1PIK3CAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |