Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900636 | 0.89 | NEK2 (0.34) | GAA | |
| SCHEMBL30154873 | 0.89 | NEK2 (0.34) | GAA | |
| SCHEMBL2355700 | 0.84 | CYP11B2 (0.40) | TDO2HRH2HRH3CYP11B2KDM4E | |
| SCHEMBL16053346 | 0.79 | OPRL1 (0.40) | TNK2 | |
| SCHEMBL28076460 | 0.79 | HRH4 (0.41) | HRH3TNK2JAK2JAK1TYK2 | |
| SCHEMBL9900173 | 0.77 | BTK (0.46) | JAK2JAK1JAK3 | |
| SCHEMBL9900029 | 0.77 | BTK (0.46) | JAK2JAK1JAK3 | |
| SCHEMBL15740601 | 0.75 | TDO2 (0.36) | TDO2HRH2HRH3CYP11B2FFAR2 | |
| SCHEMBL20136097 | 0.75 | JAK2 (0.37) | BACE1GAAJAK2JAK1TYK2 | |
| SCHEMBL7937826 | 0.74 | NISCH (0.36) | TDO2CYP11B2FFAR2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142715-A | 2-amino-5-heterocyclic group substituted pyrazine derivative and application thereof | 鲁南制药集团股份有限公司 | 2020-12-29 | — | — | CN | disclosed |