Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23489128 | 0.99 | DRD2 (0.45) | DRD2DRD3CTSCEPHX2CPB1 | |
| SCHEMBL28901075 | 0.88 | DRD2 (0.41) | DRD2DRD3CTSCEPHX2LIPG | |
| SCHEMBL20137269 | 0.88 | DRD2 (0.41) | DRD2DRD3CTSCEPHX2LIPG | |
| SCHEMBL15099494 | 0.88 | CTSC (0.48) | CTSCEPHX2CPB1CYP2C9CYP2C19 | |
| SCHEMBL8693462 | 0.88 | CTSC (0.48) | CTSCEPHX2CPB1CYP2C9CYP2C19 | |
| SCHEMBL8690915 | 0.88 | CTSC (0.48) | CTSCEPHX2CPB1CYP2C9CYP2C19 | |
| SCHEMBL23462268 | 0.87 | DRD2 (0.41) | DRD2DRD3CTSCEPHX2LIPG | |
| Hydrochloric Acid SCHEMBL3053757 | 0.87 | CTSC (0.47) | CTSCEPHX2CPB1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL7323379 | 0.87 | CTSC (0.47) | CTSCEPHX2CPB1CYP2C9CYP2C19 | |
| SCHEMBL23462212 | 0.83 | DRD2 (0.37) | DRD2DRD3CTSCEPHX2CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286169-B1 | PROTAC COMPOUNDS MODULATING RIP2 KINASE ACTIVITY | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-10-07 | — | — | EP | disclosed |
| EP-3286169-B1 | PROTAC COMPOUNDS MODULATING RIP2 KINASE ACTIVITY | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-10-07 | — | — | EP | disclosed |
| CN-107709305-B | Novel compound | 葛兰素史克知识产权开发有限公司 | 2020-09-29 | — | — | CN | disclosed |
| US-10435391-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-08 | — | — | US | disclosed |
| US-10435391-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-08 | — | — | US | disclosed |
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435391-B2 | Compounds | RIPK2, RIPK1, RIPK4 | DRD2 4536/4885DRD3 4668/4885CTSC 934/4885 |
| US-20180134688-A1 | NOVEL COMPOUNDS | RIPK2, RIPK1, RIPK4 | DRD2 4614/4885DRD3 4705/4885CTSC 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.