Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 7/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013776 | 0.84 | PIK3CD (0.42) | FFAR2METAP2ROCK2ROCK1CDC42BPB | |
| SCHEMBL2015604 | 0.82 | METAP2 (0.40) | FFAR2METAP2ROCK2ROCK1CDC42BPB | |
| SCHEMBL2017050 | 0.82 | SLC40A1 (0.40) | METAP2PIK3CD | |
| SCHEMBL2016811 | 0.81 | METAP2 (0.34) | METAP2PIK3CD | |
| SCHEMBL2017831 | 0.81 | METAP2 (0.38) | METAP2 | |
| SCHEMBL2016501 | 0.80 | KHK (0.36) | METAP2 | |
| SCHEMBL2014977 | 0.80 | SLC40A1 (0.38) | METAP2PIK3CD | |
| SCHEMBL2014980 | 0.80 | SLC40A1 (0.38) | METAP2PIK3CD | |
| SCHEMBL2012342 | 0.79 | MAPT (0.42) | METAP2 | |
| SCHEMBL2015620 | 0.79 | SMO (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |