Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2013265 | 0.94 | KHK (0.33) | KHKMETAP2MAP4K4BTK | |
| SCHEMBL2016811 | 0.89 | METAP2 (0.34) | METAP2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL2014977 | 0.88 | SLC40A1 (0.38) | METAP2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL2014980 | 0.88 | SLC40A1 (0.38) | METAP2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL2017050 | 0.86 | SLC40A1 (0.40) | METAP2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL2015211 | 0.84 | AXL (0.32) | METAP2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL2016495 | 0.83 | PIK3CD (0.42) | KHKMAP4K4KDM4ELMNAMAPT | |
| SCHEMBL2016578 | 0.83 | CNR2 (0.38) | RAB9AL3MBTL1BTKNPC1 | |
| SCHEMBL2012932 | 0.82 | ABCC1 (0.33) | METAP2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL2013366 | 0.82 | CCR4 (0.37) | METAP2LMNAMAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | claimed |