Sugi Predict

Sugi Predict / Compounds / SCHEMBL20137941

SCHEMBL20137941

SCHEMBL20137941

CC1(NC(=O)O)CCN(c2cccnc2)CC1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CHRNB2 P17787 6/20 0.46
▸ CHRNA4 P43681 6/20 0.46
▸ ADAMTS5 Q9UNA0 1/20 0.44
▸ GPR119 Q8TDV5 1/20 0.44
▸ CHRNA1 P02708 3/20 0.43
▸ CHRNG P07510 3/20 0.43
▸ CHRNB1 P11230 3/20 0.43
▸ CHRNB4 P30926 3/20 0.43
▸ CHRNA3 P32297 3/20 0.43
▸ CHRNA7 P36544 3/20 0.43
▸ CHRND Q07001 3/20 0.43
▸ TRPV1 Q8NER1 1/20 0.43
▸ CYP3A4 P08684 1/20 0.43
▸ GRM1 Q13255 1/20 0.42
▸ PHGDH O43175 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20069024 0.83 GPR119 (0.55) CHRNB2CHRNA4ADAMTS5GPR119CHRNA1
SCHEMBL29685859 0.83 GPR119 (0.55) CHRNB2CHRNA4ADAMTS5GPR119CHRNA1
SCHEMBL28147346 0.79 CHRNB2 (0.55) CHRNB2CHRNA4ADAMTS5CHRNA1CHRNG
SCHEMBL6633428 0.78 CHRNB2 (0.56) CHRNB2CHRNA4CHRNA1CHRNGCHRNB1
SCHEMBL20137572 0.77 CHRNB2 (0.48) CHRNB2CHRNA4CYP3A4
SCHEMBL5148961 0.77 KDM4E (0.51) GPR119CYP3A4
SCHEMBL4825450 0.76 CHRNB2 (0.56) CHRNB2CHRNA4CHRNA1CHRNGCHRNB1
SCHEMBL19690345 0.76 ADAMTS5 (0.44) ADAMTS5TRPV1CYP3A4
SCHEMBL644811 0.75 CHRNB2 (0.54) CHRNB2CHRNA4CHRNA1CHRNGCHRNB1
SCHEMBL29352900 0.75 CHRNB2 (0.54) CHRNB2CHRNA4CHRNA1CHRNGCHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-05-16 — — US disclosed
EP-4144735-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS Array Biopharma, Inc. (US) 2023-03-08 — — EP disclosed
EP-3523302-B1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2022-07-20 — — EP disclosed
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-01-05 — — US disclosed
US-20200383966-A9 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2020-12-10 — — US disclosed
US-20200030311-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2020-01-30 — — US disclosed
US-10441581-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-10-15 — — US disclosed
US-10172845-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-01-08 — — US disclosed
US-10144734-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2018-12-04 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200383966-A9 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-10144734-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-10441581-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-20200030311-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-10172845-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 CHRNB2 2262/4885CHRNA4 1854/4885ADAMTS5 3904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.