Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20137971 | 0.85 | SMN1; SMN2 (0.36) | SMN1; SMN2SHMT2NPC1RAB9ABRD4 | |
| SCHEMBL20138128 | 0.78 | SHMT2 (0.34) | SMN1; SMN2SHMT2NPC1RAB9A | |
| SCHEMBL20138097 | 0.76 | GRM2 (0.32) | SMN1; SMN2SHMT2NPC1RAB9AGNRHR | |
| SCHEMBL20138145 | 0.73 | HTT (0.34) | SMN1; SMN2TSHRHTTALDH1A1GNRHR | |
| SCHEMBL20138092 | 0.73 | SMN1; SMN2 (0.36) | SMN1; SMN2SHMT2NPC1RAB9AKMT2A | |
| SCHEMBL20137954 | 0.73 | HTR1A (0.38) | BRD4HTTALDH1A1KMT2A | |
| SCHEMBL20138285 | 0.73 | GALR3 (0.36) | SMN1; SMN2SHMT2NPC1RAB9ATSHR | |
| SCHEMBL20137967 | 0.72 | MAPK1 (0.43) | SHMT2BRD4KDM4E | |
| SCHEMBL20138211 | 0.72 | DRD2 (0.32) | SMN1; SMN2SHMT2NPC1RAB9ABRD4 | |
| SCHEMBL20138002 | 0.71 | SHMT2 (0.35) | SMN1; SMN2SHMT2NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10287299-B2 | Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity | UCB BIOPHARMA SPRL (BE) | 2019-05-14 | — | — | US | disclosed |
| US-20180134728-A1 | Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity | UCB S.A. (BE) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134728-A1 | Benzoxazinone Derivatives and Analogues Thereof as Modulators of TNF Activity | TNF, NFKBIA, TNFRSF1A | SMN1; SMN2 798/4885SHMT2 2782/4885NPC1 4103/4885 |
| US-10287299-B2 | Substituted benzo[b][1,4]oxazines and pyrido[3,2-b][1,4]oxazines as modulators of tumor necrosis factor activity | TNF, TNFRSF1A, NFKBIA | SMN1; SMN2 419/4885SHMT2 3128/4885NPC1 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.