Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696278 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL28468465 | 0.94 | ALDH1A1 (0.61) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL1276137 | 0.89 | HPGD (0.60) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL28763508 | 0.88 | ALDH1A1 (0.61) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL18228463 | 0.86 | HPGD (0.63) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL7131881 | 0.84 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL10559542 | 0.84 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL1309352 | 0.82 | ALDH1A1 (0.86) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL2386976 | 0.82 | ALDH1A1 (0.86) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL1826063 | 0.82 | ALDH1A1 (0.86) | ALDH1A1TSHRHPGDHSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |
| US-10590085-B2 | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-03-17 | — | — | US | disclosed |
| US-20180134665-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590085-B2 | Heterocyclic amides as kinase inhibitors | MAP3K19, MAP3K20, MAP3K1 | ALDH1A1 1542/4885TSHR 843/4885HPGD 2029/4885 |
| US-20180134665-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | MAP3K19, MAP3K20, MAP3K1 | ALDH1A1 1542/4885TSHR 843/4885HPGD 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.