Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.47 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.47 |
| ▸ | FASN | P49327 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138341 | 0.98 | ALDH1A1 (0.72) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL28468465 | 0.96 | ALDH1A1 (0.61) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL1276137 | 0.91 | HPGD (0.60) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL18228463 | 0.88 | HPGD (0.63) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL28763508 | 0.86 | ALDH1A1 (0.61) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL30929928 | 0.84 | ALDH1A1 (0.95) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL1299556 | 0.83 | HPGD (0.68) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL25243252 | 0.82 | TSHR (0.47) | ALDH1A1TSHRHPGDLMNASMN1; SMN2 | |
| SCHEMBL1199411 | 0.82 | HTT (0.53) | ALDH1A1TSHRHPGDHSD11B1LMNA | |
| SCHEMBL7131881 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDHSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-105492434-B | Miscellaneous bicyclic aryl RORC2 inhibitor and its application method | 辉瑞大药厂 | 2018-02-16 | — | — | CN | disclosed |
| CN-105492434-A | Heterobicycloaryl RORC2 inhibitors and methods of use thereof | PFIZER | 2016-04-13 | — | — | CN | disclosed |
| EP-1987037-A2 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007097470-A2 | FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-30 | — | — | WO | disclosed |