Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317481 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1MAPTHTTTDP1 | |
| SCHEMBL1451808 | 0.77 | KDM4E (0.44) | ALDH1A1GAATDP1PTGS2KDM4E | |
| SCHEMBL1205065 | 0.76 | TNFSF11 (0.46) | SMN1; SMN2ALDH1A1VCPGAAPKM | |
| SCHEMBL30520310 | 0.76 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1MAPTRECQLHTT | |
| SCHEMBL6201135 | 0.76 | TPMT (0.35) | SMN1; SMN2ALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL20138650 | 0.76 | KDM4E (0.38) | ALDH1A1GAATDP1PTGS2KDM4E | |
| SCHEMBL471777 | 0.76 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1MAPTRECQLHTT | |
| SCHEMBL3580690 | 0.75 | PDK1 (0.47) | SMN1; SMN2ALDH1A1MAPTRECQLHTT | |
| SCHEMBL4521634 | 0.75 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1MAPTRECQLGAA | |
| SCHEMBL25329772 | 0.75 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1MAPTRECQLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538080-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | Hangzhou Dac Biotech Co. Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018086139-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2018-05-17 | — | — | WO | disclosed |