Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29088338 | 0.85 | LMNA (0.49) | LMNAALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL11554391 | 0.84 | NPC1 (0.49) | LMNAALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL10626127 | 0.81 | ALDH1A1 (0.52) | LMNAALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL4176308 | 0.73 | TSHR (0.47) | LMNAALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL4176309 | 0.73 | TSHR (0.52) | LMNAALDH1A1L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL28827127 | 0.71 | NPC1 (0.43) | LMNAALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL20503326 | 0.71 | NPC1 (0.47) | LMNAALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL28045443 | 0.71 | ALDH1A1 (0.53) | LMNAALDH1A1RAB9AL3MBTL1KMT2A | |
| SCHEMBL27139938 | 0.71 | TSHR (0.58) | LMNAALDH1A1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL111605 | 0.71 | ALDH1A1 (0.68) | LMNAALDH1A1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818062-A1 | CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES | Hangzhou Dac Biotech Co., Ltd (CN) | 2021-05-12 | — | — | EP | disclosed |
| WO-2020006722-A1 | CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2020-01-09 | — | — | WO | disclosed |
| EP-3538080-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | Hangzhou Dac Biotech Co. Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018086139-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2018-05-17 | — | — | WO | disclosed |