Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14714843 | 0.84 | NPC1 (0.51) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL29088338 | 0.84 | LMNA (0.49) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL20138646 | 0.84 | LMNA (0.49) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL432494 | 0.81 | NPC1 (0.52) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL28686366 | 0.79 | SMN1; SMN2 (0.56) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL28146646 | 0.77 | RIPK1 (0.49) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL10698414 | 0.76 | CYP2C19 (0.51) | NPC1RAB9ACA12CA9RIPK1 | |
| SCHEMBL16989819 | 0.76 | RIPK1 (0.48) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL16989810 | 0.75 | RIPK1 (0.46) | NPC1RAB9ACA12CA9LMNA | |
| SCHEMBL28045443 | 0.73 | ALDH1A1 (0.53) | RAB9ALMNAALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |