Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159211 | 0.86 | SMN1; SMN2 (0.40) | GAASMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL20159752 | 0.85 | SMN1; SMN2 (0.39) | GAASMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL4940552 | 0.79 | PDE4B (0.51) | GAAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20142960 | 0.79 | SMN1; SMN2 (0.41) | GAASMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL11729834 | 0.76 | MEN1 (0.61) | GAACES2SMN1; SMN2PDE4APDE4B | |
| SCHEMBL6014950 | 0.75 | MAPT (0.42) | GAACES2SMN1; SMN2PDE4APDE4B | |
| SCHEMBL20142913 | 0.75 | SMN1; SMN2 (0.39) | GAASMN1; SMN2PDE4BMEN1MAPT | |
| SCHEMBL29394870 | 0.74 | GAA (0.76) | GAACES2SMN1; SMN2PDE4APDE4B | |
| SCHEMBL20138995 | 0.74 | PDE4A (0.45) | GAASMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL20142942 | 0.72 | PDE4A (0.44) | GAASMN1; SMN2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |