Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138975 | 1.00 | KCNH2 (0.50) | KCNH2HPGDSLC2A1POLBDRD4 | |
| SCHEMBL20138817 | 0.86 | KCNH2 (0.51) | KCNH2SLC2A1DRD4GSK3AGSK3B | |
| SCHEMBL20138818 | 0.86 | KCNH2 (0.51) | KCNH2SLC2A1DRD4GSK3AGSK3B | |
| SCHEMBL20139008 | 0.82 | LMNA (0.52) | HPGDGSK3AGSK3BABL1ESR1 | |
| SCHEMBL20139011 | 0.82 | LMNA (0.52) | HPGDGSK3AGSK3BABL1ESR1 | |
| SCHEMBL20142976 | 0.78 | HPGD (0.50) | HPGDABL1KDRMAPT | |
| SCHEMBL20142977 | 0.78 | HPGD (0.50) | HPGDABL1KDRMAPT | |
| SCHEMBL18208421 | 0.76 | NTRK1 (0.48) | HPGDPOLBDRD4CDK1CDK2 | |
| SCHEMBL18208418 | 0.76 | NTRK1 (0.48) | HPGDPOLBDRD4CDK1CDK2 | |
| SCHEMBL20161124 | 0.73 | HPGD (0.47) | HPGDPOLBGSK3AGSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | claimed |
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |