Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142977 | 0.89 | HPGD (0.50) | HPGDPDE4BGRM4MAPTCNR1 | |
| SCHEMBL20142976 | 0.89 | HPGD (0.50) | HPGDPDE4BGRM4MAPTCNR1 | |
| SCHEMBL20142963 | 0.80 | HPGD (0.46) | HPGDPDE4BGRM4MAPTCNR1 | |
| SCHEMBL20142964 | 0.80 | HPGD (0.46) | HPGDPDE4BGRM4MAPTCNR1 | |
| SCHEMBL20139011 | 0.80 | LMNA (0.52) | HPGDPDE4BGRM4MAPTGSK3A | |
| SCHEMBL20139008 | 0.80 | LMNA (0.52) | HPGDPDE4BGRM4MAPTGSK3A | |
| SCHEMBL20143016 | 0.76 | HPGD (0.49) | HPGDPDE4BGRM4MAPTCNR1 | |
| SCHEMBL20143015 | 0.76 | HPGD (0.49) | HPGDPDE4BGRM4MAPTCNR1 | |
| SCHEMBL18209027 | 0.75 | IRAK4 (0.50) | HPGD | |
| SCHEMBL18209030 | 0.75 | IRAK4 (0.50) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087126-A1 | AMIDO-SUBSTITUTED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF TANKYRASE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |