Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.67 |
| ▸ | BTK | Q06187 | 6/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 4/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139083 | 0.93 | EGFR (0.70) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL20139118 | 0.86 | EGFR (0.64) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL20139048 | 0.83 | SRC (0.59) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL7237980 | 0.80 | EGFR (0.84) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL7239977 | 0.80 | EGFR (1.00) | EGFRERBB2BTKFYNSRC | |
| SCHEMBL690318 | 0.77 | TGM2 (0.71) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL20139002 | 0.77 | PIK3CD (0.55) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL20150686 | 0.77 | EGFR (0.50) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL7241722 | 0.76 | EGFR (0.76) | EGFRERBB2BTKKCNH2FYN | |
| SCHEMBL7238977 | 0.76 | EGFR (0.73) | EGFRERBB2BTKKCNH2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018088780-A1 | NOVEL PYRROLOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-05-17 | — | — | WO | claimed |
| WO-2018088780-A1 | NOVEL PYRROLOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-05-17 | — | — | WO | disclosed |