Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140205 | 0.91 | GRM1 (0.47) | GRM1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL20157461 | 0.79 | GHSR (0.44) | GRM1KDM4EALDH1A1GRM5GRM2 | |
| SCHEMBL30619380 | 0.77 | GRM1 (0.49) | GRM1KDM4EALDH1A1GRM5GRM2 | |
| SCHEMBL20129652 | 0.77 | GRM1 (0.46) | GRM1KDM4EALDH1A1GRM5GRM2 | |
| SCHEMBL27488325 | 0.77 | GRM1 (0.49) | GRM1KDM4EALDH1A1GRM5GRM2 | |
| SCHEMBL21667804 | 0.76 | BPTF (0.53) | GRM1CHRNB2CHRNA4KDM4EGRM5 | |
| SCHEMBL20139988 | 0.76 | USP25 (0.38) | CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL20157244 | 0.75 | GRM1 (0.43) | GRM1CHRNB2CHRNA4KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL20511262 | 0.75 | BPTF (0.51) | GRM1CHRNB2CHRNA4KDM4EGRM5 | |
| SCHEMBL19665127 | 0.74 | GRM1 (0.47) | GRM1KDM4EALDH1A1GRM5GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |