Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157269 | 0.81 | ALDH1A1 (0.36) | KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL20140205 | 0.77 | GRM1 (0.47) | GRM1GRM5KDM4EDRD4DRD2 | |
| SCHEMBL12835705 | 0.75 | DPP4 (0.47) | GRM1GRM5KDM4EALDH1A1 | |
| SCHEMBL20129683 | 0.75 | DPP4 (0.47) | GRM1GRM5KDM4EALDH1A1 | |
| SCHEMBL20139200 | 0.75 | GRM1 (0.43) | GRM1GRM5KDM4EALDH1A1CHRNB2 | |
| SCHEMBL23702949 | 0.74 | AR (0.55) | GRM1GRM5KDM4EALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL1514528 | 0.74 | DPP4 (0.47) | GRM1GRM5KDM4EALDH1A1 | |
| SCHEMBL23708047 | 0.74 | AR (0.55) | GRM1GRM5KDM4EALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL1514285 | 0.74 | DPP4 (0.47) | GRM1GRM5KDM4EALDH1A1 | |
| SCHEMBL23708107 | 0.74 | AR (0.55) | GRM1GRM5KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |