Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 11/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139336 | 1.00 | SUV39H2 (0.47) | SUV39H2MAP4K4NR1H2NR1H3CHRM5 | |
| SCHEMBL20157181 | 0.93 | GHSR (0.49) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL4589914 | 0.84 | SUV39H2 (0.47) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL4589911 | 0.84 | SUV39H2 (0.47) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL1537817 | 0.82 | MAPT (0.53) | GPR119 | |
| SCHEMBL20139589 | 0.79 | NR1H2 (0.59) | SUV39H2MAP4K4NR1H2NR1H3CHRM1 | |
| SCHEMBL20159029 | 0.79 | SUV39H2 (0.49) | SUV39H2MAP4K4NR1H2NR1H3GPR119 | |
| SCHEMBL24792767 | 0.78 | NR1H2 (0.44) | SUV39H2MAP4K4NR1H2NR1H3FAAH | |
| SCHEMBL24792791 | 0.78 | NR1H2 (0.44) | SUV39H2MAP4K4NR1H2NR1H3FAAH | |
| SCHEMBL15441723 | 0.78 | GPR119 (0.51) | SUV39H2MAP4K4NR1H2NR1H3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |