Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139363 | 1.00 | GRM2 (0.32) | GRM2GRM3ALDH1A1MAPK1CYP2C19 | |
| SCHEMBL25364146 | 0.87 | GRM2 (0.36) | GRM2GRM3CYP2C19 | |
| SCHEMBL21806853 | 0.87 | GRM2 (0.36) | GRM2GRM3CYP2C19 | |
| SCHEMBL22636144 | 0.84 | GRM2 (0.34) | GRM2GRM3CYP2C19 | |
| SCHEMBL25365226 | 0.84 | GRM2 (0.34) | GRM2GRM3CYP2C19 | |
| SCHEMBL10179303 | 0.79 | PEPD (0.34) | GRM2GRM3 | |
| SCHEMBL20139027 | 0.79 | CYP1A2 (0.34) | GRM2GRM3 | |
| SCHEMBL20139024 | 0.79 | CYP1A2 (0.34) | GRM2GRM3 | |
| SCHEMBL10179199 | 0.79 | GRM2 (0.32) | GRM2GRM3 | |
| SCHEMBL22518862 | 0.78 | CYP2C19 (0.33) | GRM2GRM3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708365-B2 | Processes for preparing TPH1 inhibitors | ALTAVANT SCIENCES GMBH | 2023-07-25 | — | — | US | disclosed |
| EP-3538530-B1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | ALTAVANT SCIENCES GMBH (CH) | 2022-01-05 | — | — | EP | disclosed |
| US-20210139481-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2021-05-13 | — | — | US | disclosed |
| EP-3538530-A1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | Altavant Sciences GmbH (CH) | 2019-09-18 | — | — | EP | disclosed |
| US-20190263815-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2019-08-29 | — | — | US | disclosed |
| WO-2018087602-A1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | ROIVANT SCIENCES GMBH (CH) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263815-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | TPH1, TPH2, HTR1A | GRM2 1904/4885GRM3 1693/4885ALDH1A1 197/4885 |
| US-11708365-B2 | Processes for preparing TPH1 inhibitors | TPH1, TPH2, HTR1A | GRM2 1963/4885GRM3 1749/4885ALDH1A1 194/4885 |
| US-20210139481-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | TPH1, TPH2, HTR1A | GRM2 1963/4885GRM3 1749/4885ALDH1A1 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.