Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139779 | 0.86 | TSHR (0.62) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL20141475 | 0.83 | TSHR (0.77) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL17809495 | 0.73 | GRM2 (0.58) | TSHRHTTALDH1A1L3MBTL1GRM2 | |
| SCHEMBL24187528 | 0.72 | ALDH1A1 (0.51) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL12369545 | 0.71 | POLB (0.60) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL12890511 | 0.70 | ALDH1A1 (0.54) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL14191672 | 0.70 | ALDH1A1 (0.56) | TSHRHTTMAPTALDH1A1L3MBTL1 | |
| SCHEMBL25419579 | 0.69 | NR1H2 (0.44) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL9968767 | 0.69 | NR1H2 (0.44) | TSHRHTTMAPTPOLBSMN1; SMN2 | |
| SCHEMBL839899 | 0.69 | ALDH1A1 (0.50) | TSHRHTTMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4638455-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024138048-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2024-06-27 | — | — | WO | disclosed |