Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 7/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140937 | 0.81 | MTOR (0.55) | GRM1CYP2D6CYP3A4DRD2CHRM2 | |
| SCHEMBL20141221 | 0.81 | CHRM2 (0.49) | GRM1CYP2D6CYP3A4CHRM2CHRM4 | |
| SCHEMBL20140156 | 0.80 | CHRM2 (0.57) | GRM1CHRM2CHRM4 | |
| SCHEMBL30607698 | 0.79 | GRM1 (0.54) | GRM1CYP2D6CYP3A4DRD2DRD4 | |
| SCHEMBL20139213 | 0.78 | FAAH (0.54) | GRM1CTSBCTSSCTSKCHRM4 | |
| SCHEMBL27606539 | 0.78 | FAAH (0.54) | GRM1CTSBCTSSCTSKCHRM4 | |
| SCHEMBL25330081 | 0.78 | GRM1 (0.44) | GRM1CYP2D6CYP3A4CHRM2CHRM4 | |
| SCHEMBL4088121 | 0.77 | CHRM4 (0.48) | GRM1CHRM4 | |
| SCHEMBL5369598 | 0.75 | GRM5 (0.60) | DRD2DRD4GRM5DRD3MC4R | |
| SCHEMBL20158994 | 0.74 | MTOR (0.53) | GRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |