Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141742 | 0.84 | MTOR (0.47) | MTORRPTORMLST8JAK2JAK1 | |
| SCHEMBL20156791 | 0.81 | MTOR (0.52) | MTORRPTORMLST8GRM2JAK2 | |
| SCHEMBL20139980 | 0.75 | MTOR (0.46) | MTORRPTORMLST8BRD4RET | |
| SCHEMBL20156834 | 0.74 | MTOR (0.54) | MTORRPTORMLST8JAK2JAK1 | |
| SCHEMBL20157463 | 0.71 | GRM1 (0.41) | MTORRPTORMLST8GRM2BRD4 | |
| SCHEMBL20140731 | 0.70 | DRD4 (0.54) | MTORRPTORMLST8KDM4EHTR7 | |
| SCHEMBL19013673 | 0.69 | BRD4 (0.44) | MTORRPTORMLST8JAK2JAK1 | |
| SCHEMBL20157462 | 0.69 | KDM4E (0.40) | MTORRPTORMLST8BRD4KDM4E | |
| SCHEMBL20156863 | 0.69 | DRD4 (0.53) | MTORRPTORMLST8KDM4EHTR7 | |
| SCHEMBL1843465 | 0.64 | ALDH1A1 (0.51) | BRD4C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |