Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139227 | 0.93 | GPR119 (0.53) | GPR119RETGRM1GRM5CHRM2 | |
| SCHEMBL2456832 | 0.81 | GRM1 (0.56) | GPR119GRM1GRM5NR1H2 | |
| SCHEMBL20140595 | 0.80 | GRM1 (0.50) | GRM1GRM5 | |
| SCHEMBL29385182 | 0.80 | TLR8 (0.52) | GPR119RETJAK1 | |
| SCHEMBL30607714 | 0.80 | PARP1 (0.48) | GPR119RETGRM1GRM5AR | |
| SCHEMBL20157245 | 0.80 | GRM1 (0.46) | GPR119GRM1GRM5ARHSD11B1 | |
| SCHEMBL19838611 | 0.79 | GPR119 (0.54) | GPR119RETCHRM2CHRM1CHRM3 | |
| SCHEMBL21142472 | 0.79 | GPR119 (0.54) | GPR119RETCHRM2CHRM1CHRM3 | |
| SCHEMBL19838612 | 0.79 | GPR119 (0.54) | GPR119RETCHRM2CHRM1CHRM3 | |
| SCHEMBL19838613 | 0.79 | GPR119 (0.54) | GPR119RETCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |