Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139540 | 0.91 | GRM1 (0.47) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL20139986 | 0.80 | GPR119 (0.46) | GRM1GRM5 | |
| SCHEMBL20140686 | 0.78 | GRM1 (0.64) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL20141122 | 0.75 | GRM1 (0.48) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL27488325 | 0.74 | GRM1 (0.49) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL30619380 | 0.74 | GRM1 (0.49) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL19211089 | 0.72 | ALDH1A1 (0.41) | DRD4KMT2A | |
| SCHEMBL20139227 | 0.72 | GPR119 (0.53) | GRM1GRM5CHRM4 | |
| SCHEMBL20139980 | 0.72 | MTOR (0.46) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL5369598 | 0.72 | GRM5 (0.60) | GRM5DRD2DRD4DPP4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |